The modern ozone-oxygen generator is used for the removal of amalgam fillings. During systematic amalgam removal there is an increased potential for released radicals such as mercury, silver or copper. In addition to other preventive measures such as a rubber dam or special suction device, nasal administration of pure oxygen to stabilize the immune system is urgently indicated.

Ozone (O3) is normally produced by dissociation of molecular oxygen (O2) into activated oxygen atoms. There is a high oxidation potential in ozone gas and it is more effective than chloride when used as an antimicrobial agent against bacteria and viruses. Ozone also has the ability to increase blood circulation as well as the immune response.